hrp0086p1-p254 | Diabetes P1 | ESPE2016

A Case-Control Search of Environmental (E) Factors for Childhood Type 1 Diabetes (T1D) Using Lifeline Questionnaires in the ISIS-Diab Cohort

Balazard Felix , Le Fur Sophie , Biau Gerard , Valleron Alain-Jacques , Bougneres Pierre

Background: The rapidly increasing T1D incidence in European children suggests the recent emergence or extension of predisposing E factors, or the decrease of protective E factors acting during pregnancy, infancy or early childhood. E research has preferentially focused on specific candidate factors, such as hygiene hypothesis, enteroviruses, alimentation, in cohort or case-control studies. The risk of bias is a major concern in E studies.Objectives: To ...